Jaw problems associated with Zoledronic acid use

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There are studies exploring jaw problems related to excessive Zoledronic acid use. This injection is mainly given in those conditions of cancer spread where there is excessive pain, bone fracture and other associated problems. The regular use of such drugs which modify the action of bone are being used rapidly. But there are eventually underlying problems which will be explored through this blog.

What is osteonecrosis of the jaw?

The power of Zoledronic acid Injection has its effects on the lower jaw. Where there is no proper gum formation and hence the lower region of the jawline does not hold properly over a period of time to these bones. Henceforth, there is eventual disfigurement or complete alterations in the face structure.

Doctors still do not have any clue or idea as to how this condition developed. Still, there are likely cases being almost one to fifteen percent. Followed by another study, where this condition on three thousand five hundred people increased by one percent in the first year, then two percent in the second and three percent in the third year.

The NCI based study stated that poor oral hygiene, like people not brushing their teeth properly or on time and smoking, drinking alcohol etc., increases the risk of developing this condition in these patients.

How to prevent this condition?

The doctors can give Zoledronic acid injection once every 12 weeks which has same effects as giving it once in every four weeks. The research scientists from their clinical-based study protocol have also reached an understanding that patients can also play a good role in reducing the symptoms related to osteonecrosis of the jaw. Likewise, they are suggesting healthcare professionals to urge patients to keep a proper and well-mannered oral hygiene. This is very important to prevent complications associated with this condition.

Link between osteonecrosis and poor dental hygiene

Zoledronic acid and other forms of similar drugs containing bisphosphonates, will interrupt with the breakdown of bone tissue. These drugs also interfere and intervene unnaturally in the normal process of breakdown and rebuilding the bone tissue all over the body in a healthy way.

In the year of 2003, these oral or dental-specific surgeons noticed that patients who took these similar bisphosphonate-related drugs had developed osteonecrosis of the jaw. This condition was in fact rarely ever seen before the process through which bisphosphonates because this condition is unknown and is hard enough to treat even with the latest developments in advanced technology as of now.

Currently, it has also been noticed that patients who smoke were more likely to develop this condition as much as nonsmokers. In addition, patients who doses of Zoledronic acid injection 4mg in large amounts within the first year of treatment were unrecognizably more prone to this condition also. Then the patients who had received it after a few years or comparatively after extended weeks too.

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